Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study.

• Tác giả: Fang Ren, Jin Zhang, Lili Zhang, Di Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: England : BMC pulmonary medicine , 2025
• Bộ sưu tập: NCBI
• ID: 696847

Tóm tắt

 BACKGROUND: Epidemiological investigations provide considerable evidence supporting the coexistence of upper airway ailments with lower airway disorders, but the association between common nasal diseases, such as allergic rhinitis, chronic sinusitis, nasal polyps, and chronic respiratory conditions require further exploration. METHODS: In this study, a two-sample mendelian randomization was employed to explore the potential association between allergic rhinitis, nasal polyps, and chronic sinusitis with various chronic respiratory diseases. For the primary analysis, summary statistics related to chronic respiratory diseases were obtained from the UK Biobank of European ancestry. To externally validate the results, summary statistics related to chronic respiratory diseases were sourced from the FinnGen R10 database. The analysis incorporated various methodologies, including the inverse variance weighted method, the MR Egger method, and the weighted median method. Sensitivity analysis encompassed Cochran 's Q test, MR-Egger intercept tests, leave-one-out analyses, and the construction of funnel plots. RESULTS: Allergic rhinitis was significantly associated with asthma (UKB database, OR 1.082, 95% CI 1.072-1.0924, P <
  0.001
  FinnGen database, OR 1.382, 95% CI 1.305-1.462, P <
  0.001), COPD (UKB database, OR 1.003, 95% CI 1.001-1.006, P = 0.020
  FinnGen database, OR 1.102, 95% CI 1.037-1.172, P = 0.002), ILD (UKB database, OR 1.013, 95% CI 1.010-1.017, P <
  0.001
  FinnGen database, OR 1.152, 95% CI 1.035-1.283, P = 0.010). Nasal polyps were potentially related to the increased risks of COPD (UKB database, OR 1.003, 95% CI 1.001-1.004, P <
  0.001
  FinnGen database, OR 1.092, 95% CI 1.050-1.136, P <
  0.001) and bronchiectasis (UKB database, OR 1.000, 95% CI 1.000-1.001, P = 0.036
  FinnGen database, OR 1.109, 95% CI 1.022-1.203, P = 0.013). CONCLUSIONS: This study indicates a potential relationship between allergic rhinitis and respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Additionally, the presence of nasal polyps appears to be correlated with an increased prevalence of COPD and bronchiectasis.