OBJECTIVE: This study was aimed at exploring the safety and timing of functional endoscopic sinus surgery (FESS) in patients after mild-to-moderate SARS-CoV-2 infection. METHODS: The study group comprised 63 adult inpatients who underwent FESS in our department after mild-to-moderate SARS-CoV-2 infection between December 2022 and February 2023. Sixty adult patients without prior SARS-CoV-2 infection were randomly selected as the control group. The surgical time, intraoperative bleeding, postoperative epithelialization time and postoperative complications in each group were recorded, and statistical analysis was conducted with independent sample t-tests. RESULTS: Statistical analysis of the surgical time, intraoperative bleeding and postoperative epithelialization time showed no statistically significant differences between the study group and control group (p >
0.05). No postoperative complications were observed in either group. CONCLUSION: FESS is safe and effective for patients after mild-to-moderate SARS-CoV-2 infection if the symptoms have essentially resolved at least 15 days before surgery.