Identification of a Selective Anticancer Agent from a Collection of Complex-And-Diverse Compounds Synthesized from Stevioside.

• Tác giả: Kyle R Abo, Samantha L Barlock, Maryam Ghavami, Paul J Hergenrother, Hyang Yeon Lee, Jonathan C K Quirke, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Rachel E Schaaf, Emily J Tonogai, Thomas R Trzupek
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 697003

Tóm tắt

 Compounds constructed by distorting the ring systems of natural products serve as a ready source of complex and diverse molecules, useful for a variety of applications. Herein is presented the use of the diterpenoids steviol and isosteviol as starting points for the construction of >
 50 new compounds through this complexity-to-diversity approach, featuring novel ring system distortions and a noteworthy thallium(III) nitrate (TTN)-mediated ring fusion. Evaluation of this collection identified