UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.

• Tác giả: Brian Branchford, Deborah DeRyckere, Douglas K Graham, Justus M Huelse, Samantha Judd, Adam Kidwell, Dmitri Kireev, Deyu Kong, Stephanie Springborn, Michael A Stashko, Xiaodong Wang, Dan Yan, Xiangbo Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 940.142 800—899
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 697167

Tóm tắt

TYRO3 plays a critical role in platelet aggregation as a platelet response amplifier. Selective inhibition of TYRO3 may provide therapeutic benefits for treating thrombosis and related diseases without increasing bleeding risk. We employed a structure-based approach and discovered a novel and potent TYRO3 inhibitor UNC9426 (