Pregnenolone Sulfate Permeation at the Blood-Brain Barrier is Independent of OATP2B1-In Vivo and In Vitro Insights.

• Tác giả: Alaa Al-Khatib, Jonny Hanna Kinzi, Stefan Oswald, Anima M Schäfer, Henriette E Meyer Zu Schwabedissen, Isabell Seibert, Valerio Taggi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: England : Biopharmaceutics & drug disposition , 2025
• Bộ sưu tập: NCBI
• ID: 697208

Tóm tắt

Sulfated steroids such as pregnenolone sulfate (PregS) are important for neuronal development and cognitive functions. Given the hydrophilic sulfate moiety, it is assumed that PregS requires an active transport mechanism to cross the blood-brain barrier (BBB). The human organic anion transporting polypeptide (OATP)2B1 has been previously shown to transport sulfated steroids and is therefore a proposed candidate for the transport of PregS. In this study, we aimed to investigate the role of OATP2B1 in the uptake of PregS in the brain. Tritium-labeled PregS was intravenously administered to humanized (SLCO2B1