Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis.

• Tác giả: Lijian Cao, Kai Huang, Suwen Li, Yue Ma, Shan Wang, Linyu Yang, Zhenzhen Zhao, Jianwu Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 784.190287 General principles, musical forms, instruments
• Thông tin xuất bản: Netherlands : Genes & diseases , 2025
• Bộ sưu tập: NCBI
• ID: 697256

Tóm tắt

The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM) and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiting therapeutic strategies. Feature recognition of 142 paraffin-embedded hematoxylin-eosin-stained tumor section images was conducted using a Swin-Transformer for pathological histology to predict NB-BBM occurrence. Single-cell transcriptomics identified a tumor cell subpopulation (NB3) and two tumor-associated macrophage (TAM) subpopulations (SPP1