UNLABELLED: Asymmetric crying facies (ACF) due to Congenital hypoplasia of the depressor anguli oris muscle (CHDAOM) is a rare congenital condition that affects the development of a specific facial muscle responsible for depressing the corner of the mouth. CHDAOM has an unknown aetiology but is associated with other genetic syndromes like DiGeorge syndrome and Cayler cardiofacial syndrome. We report a distinct case of a newborn with unilateral asymmetric crying facies at our hospital, and clinical features, examination, and management of the above condition.The overarching goal is to enhance awareness, understanding, and management of CHDAOM, ultimately improving the lives of those affected by it. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12070-024-05230-5.