UNLABELLED: The jaws are affected secondarily by metastasis from a distant site. Metastatic lesions of jaws are very rare and constitute about 1% of all the malignancies occurring in the jaw, and the pattern of metastasis differs by age and sex. The objective of this review was to analyze the pattern of metastatic jaw lesions and its outcome. This was a systematic review of cases of metastatic jaw lesions published between 1950 and 2022. An electronic search of PubMed, Scopus, Web of Science, African Journals Online, and Google Scholar was performed. Only case reports or case series with histopathological results demonstrating metastasis to the jaws were included. The main outcomes included demographics, primary site, metastatic site, clinical manifestations, and patient survival. Descriptive and multivariate analysis and a Kaplan-Meier survival curve were performed. A total of 450 articles were selected with a total of 594 cases. The mean age of the patients was 54.31 (SD = 19.49) years with a median age of 58 (IQR = 47-68) years. There were slightly more females ( SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12070-024-05120-w.