Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the mouse craniofacial development.

• Tác giả: Chengyan Chen, Zhong-Min Dai, Weiran He, Caiyan Huang, Suman Huo, Xiaoning Jiang, Tangliang Li, Yeqing Qian, Mengsheng Qiu, Xueqin Yang, Jiannan Zhang, Shicheng Zhu, Xiao-Jing Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 673.73 Metals used in ferroalloys
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 698272

Tóm tắt

The specific roles of nonsense-mediated mRNA decay (NMD), a translation-dependent RNA quality control mechanism that degrades mRNAs containing premature termination codons (PTCs), in mammalian craniofacial development have remained unclear. Here, we show that knockout of the essential NMD factor