Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study.

• Tác giả: Zeynep Köksal, Halil Şenol
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Archiv der Pharmazie , 2025
• Bộ sưu tập: NCBI
• ID: 698583

Tóm tắt

This study investigates the anticholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]) and carbonic anhydrase (CAI and CAII) inhibitory activities of carnosic acid and its natural derivatives, including carnosol, rosmanol, 7-methoxy-rosmanol, 12-methoxy-carnosic acid, and isorosmanol. Among the tested compounds, rosmanol demonstrated exceptional potency, with IC