BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc.

• Tác giả: Frank Abendroth, Marina Gerhard, Dmitri Kosenkov, Crispin Lichtenberg, Alexander Schauerte, Olalla Vázquez, Valeska Viereckt
• Ngôn ngữ: eng
• Ký hiệu phân loại: 294.3823 Buddhism
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 698627

Tóm tắt

We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet oxygen. Bioluminescence imaging-guided photodynamic therapy or