Characterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach.

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Tác giả: Emmeke Aarts, G Paul Amminger, Blake Cavve, Scott Clark, Dominic Dwyer, Caroline X Gao, Jessica A Hartmann, Simon Hartmann, Ashleigh Lin, Patrick D McGorry, Barnaby Nelson, Josh Nguyen, Esdras Raposo de Almeida, Isabelle Scott, Andrew Thompson, David van den Berg, Sara van der Tuin, Cassandra Wannan, Johanna T W Wigman, Stephen J Wood, Alison R Yung

Ngôn ngữ: eng

Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons

Thông tin xuất bản: England : Psychological medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 698665

 BACKGROUND: To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time. METHODS: Data came from a 90-day daily diary study evaluating attenuated psychotic and affective symptoms. The sample included 96 individuals aged 18-35 on the psychosis continuum, divided into four subgroups of increasing severity based on their psychometric risk of psychosis, with the fourth meeting ultra-high risk (UHR) criteria. A multilevel hidden Markov modelling (HMM) approach was used to characterise and determine the probability of switching between symptomatic substates. Individual substate trajectories and time spent in each substate were subsequently assessed. RESULTS: Four substates of increasing psychopathological severity were identified: (1) low-grade affective symptoms with negligible psychotic symptoms
  (2) low levels of nonbizarre ideas with moderate affective symptoms
  (3) low levels of nonbizarre ideas and unusual thought content, with moderate affective symptoms
  and (4) moderate levels of nonbizarre ideas, unusual thought content, and affective symptoms. Perceptual disturbances predominantly occurred within the third and fourth substates. UHR individuals had a reduced probability of switching out of the two most severe substates. CONCLUSIONS: Findings suggest that individuals reporting unusual thought content, rather than nonbizarre ideas in isolation, may exhibit symptom dynamics with greater psychopathological severity. Individuals at a higher risk of psychosis exhibited persistently severe symptom dynamics, indicating a potential reduction in psychological flexibility.
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