BACKGROUND: The social and structural determinants of health (SSDOH) should be threaded throughout prelicensure nursing curriculum. However, resources to support nursing instructors in fostering these skills in the clinical setting are lacking. METHOD: Development of an SSDOH-focused clinical debriefing guide occurred across several phases that included defining the problem, engaging clinical instructors, consulting the literature, and obtaining validation. RESULTS: Clinical instructors completed a survey about a draft SSDOH clinical debriefing guide. Descriptive analysis revealed 87% to 94% of the instructors found each component of the guide to be effective or very effective in facilitating learning about SSDOH. The likelihood of using the activities and prompts during future clinical experiences ranged from 91% to 97%. CONCLUSION: Teaching resources such as this debriefing guide may make SSDOH more explicit and meaningful for nursing students during postclinical debriefing as they develop the critical skills necessary to reduce health inequity.