Chronic Pain Induced by Social Defeat Stress in Juvenile Mice Depends on TLR4.

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Tác giả: Julia Borges Paes Lemes, Maripat Corr, Sara Anna Dochnal, Maksim Dolmat, Kaue Franco Malange, Saee Jadhav, Yury I Miller, Carlos E Morado-Urbina, Juliana M Navia-Pealez, Marco Pagliusi, Alisa Panichkina, Tony L Yaksh

Ngôn ngữ: eng

Ký hiệu phân loại: 629.133349 Aerospace engineering

Thông tin xuất bản: Switzerland : Cells , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 698926

A significant portion of adolescents suffer from mental illnesses and persistent pain due to repeated stress. The components of the nervous system that link stress and pain in early life remain unclear. Prior studies in adult mice implicated the innate immune system, specifically Toll-like receptors (TLRs), as critical for inducing long-term anxiety and pain-like behaviors in social defeat stress (SDS) models. In this work, we investigated the pain and anxiety behavioral phenotypes of wild-type and TLR4-deficient juvenile mice subjected to repeated SDS and evaluated the engagement of TLR4 by measuring dimerization in the spinal cord, dorsal root ganglia, and prefrontal cortex. Male juvenile (4-week-old) mice (C57BL/6J or
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