Sex Disparities in P53 Regulation and Functions: Novel Insights for Personalized Cancer Therapies.

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Tác giả: Giacomo Buscemi, Miriana Cardano, Laura Zannini

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Cells , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 698966

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Epidemiological studies have revealed significant sex differences in the incidence of tumors unrelated to reproductive functions, with females demonstrating a lesser risk and a better response to therapy than males. However, the reasons for these disparities are still unknown and cancer therapies are generally sex-unbiased. The tumor-suppressor protein p53 is a transcription factor that can activate the expression of multiple target genes mainly involved in the maintenance of genome stability and tumor prevention. It is encoded by

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