UNLABELLED: Four-dimensional flow cardiovascular magnetic resonance (4D Flow cardiac MRI) is an advanced non-invasive imaging technology, and its derived kinetic energy (KE) blood flow parameters have been confirmed as a potential biomarkers for assessing ventricular hemodynamics. This review synthesizes details on the methodology, clinical significance, and current status of studies focused on quantifying KE parameters of the ventricle using 4D Flow cardiac MRI, providing an objective foundation for further exploration of the value of KE in cardiac diseases. STUDY TYPE: retrospective. SUBJECTS: This review includes studies that utilized 4D Flow cardiac MRI in human subjects, focusing on the changes in KE parameters. Field Strength: 1.5T or 3T. ASSESSMENT: A systematic review was conducted to assess the literature on the intracardiac clinical applications of 4D Flow cardiac MRI. In September 2024, searches were performed in PubMed, Web of Science, SCIENCEDIRECT, and Springer Link databases using the keywords "4D Flow cardiac MRI," "ventricular kinetic energy," and "intraventricular hemodynamics," covering a period of 10 years. The inclusion criteria for the literature were: (1) clinical trials with human subjects
(2) studies that addressed the value of 4D Flow cardiovascular magnetic resonance and its derived blood flow KE parameters in quantifying ventricular blood flow. The exclusion criteria were: (1) animal experimental studies
(2) non-English core journal articles. Out of the 195 articles screened, 62 studies met the criteria for the systematic review. The included literature comprised 26 (41.9%) studies on 4D Flow cardiac MRI technology and blood flow parameter research, and 36 (58.1%) clinical application studies. KE measurement using 4D Flow cardiac MRI is a promising tool for evaluating ventricular hemodynamics. It provides clinicians with deeper insights into the physiological and pathological dynamics of ventricular blood flow, from healthy states to disease.