N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii.

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Tác giả: Hans Bakker, Vanessa Horn, Andreas Pich, Françoise H Routier, Birgit Tiemann, Patricia Zarnovican

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: Germany : Proteomics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 699274

Protein N-glycosylation influences protein folding, stability, and trafficking, and has prominent functions in cell-cell adhesion and recognition. For the parasite Toxoplasma gondii, N-glycosylation of proteins is crucial for initial adhesion to host cells, parasite motility, and consequently, its ability to invade host cells. However, the glycoproteome of T. gondii remains largely unknown. In this study, we used the α-mannose-specific Burkholderia cenocepacia lectin A (BC2L-A) to enrich glycopeptides from T. gondii tachyzoites and analysed them by tandem mass spectrometry. The data enable the identification of over 100 N-glycoproteins with the glycosylation site(s) and the composition of the N-glycans at each site. T. gondii glycoproteins include known virulence factors, vaccine candidates as well as numerous uncharacterised proteins. These data provide ground knowledge to deepen our understanding of the role of glycoproteins in invasion and assist the rational design of vaccines.
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