Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.

• Tác giả: Yuting Cao, Hongfeng Cheng, Xiaoying Dong, Hongye He, Pan Li, Xingsheng Li, Ying Liu, Jianli Ren, Rui Tang, Can Wang, Nianhong Wu, Liping Yang, Yue Zhan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577 Ecology
• Thông tin xuất bản: England : Journal of nanobiotechnology , 2025
• Bộ sưu tập: NCBI
• ID: 69939

Tóm tắt

Early identification and treatment of ventricular remodeling (VR) are crucial for delaying the progression of heart failure after myocardial infarction. This study aims to develop a dual-responsive phase-shift molecular probe loaded with a cholecystokinin octapeptide (CCK-8) and oxygen, which will provide a new integrated scheme for the assessment and treatment of VR. Biocompatible phospholipid shells were utilized to encapsulate CCK-8 and perfluoropentane (PFP), an efficient oxygen carrier. Surface modification involves reactive oxygen species (ROS)-responsive thioketal (TK) bonds and anti-ICAM-1 antibodies to create CCK-8 and oxygen-carrying phase-shift nanoparticles (PFP-O