Synthesis and characterization of novel bis(thiosemicarbazone) complexes and investigation of their acetylcholinesterase and glutathione S-transferase activities with in silico and in vitro studies.

• Tác giả: Ragip Adiguzel, Naki Colak, Melike Donmez, Ercan Oğuz, Memet Sekerci, Fikret Türkan, Umit Yildiko
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Molecular diversity , 2025
• Bộ sưu tập: NCBI
• ID: 699672

Tóm tắt

In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2'-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the reaction of obtained ligand (L) with CuCl