Network pharmacology analysis and molecular mechanism of paeoniflorin and its metabolite in prolactinoma cells.

• Tác giả: Min Cao, Bin-Bin Fan, Ping Huang, Lun-Shan Xu, Yi-Hua Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.384196 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting
• Thông tin xuất bản: Netherlands : Molecular diversity , 2025
• Bộ sưu tập: NCBI
• ID: 699816

Tóm tắt

Prolactinoma was the most common functional pituitary neuroendocrine tumor tissue type, which was caused by excessive proliferation of pituitary prolactin (PRL) cells. Drug therapy of dopamine receptor agonists was generally considered as the prior treatment for prolactinoma patients. However, there were still prolactinoma patients who were resistant to dopamine agonists. Studies have been reported that paeoniflorin can inhibit the secretion of PRL in prolactinoma cells lacking dopamine D