Synthesis and Cytotoxic Activities of Novel Ether Conjugates of Dihydroartemisinin and Zerumbone: Evidenced by Integrating Network Pharmacology and In Vitro Assay.

• Tác giả: Manh Cuong Nguyen, Xuan Ha Nguyen, The Hai Pham, Phi Hung Nguyen, Ngoc Hung Truong, Thanh Loc Vu, Van Chinh Luu, Huu Nghi Do, Hanh Trang Luu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: Switzerland : Chemistry & biodiversity , 2025
• Bộ sưu tập: NCBI
• ID: 699926

Tóm tắt

O-alkylation of the hydroxy compounds, including acetaminophen, starting compounds for the synthesis of the drug, and natural compounds with the bromides of dihydroartemisinin (DHA) and zerumbone, produced twenty novel ether conjugates 15a-j and 16a-j, respectively. Their structures were elucidated by 1D-, 2D-NMR, and HRMS data. Their in vitro cytotoxic activity was screened using three cancer cell lines: HepG2, HeLa, and PC-12. The results showed that eight out of ten conjugates in series 15a-j containing DHA skeleton exhibited activity against the tested cell lines, with IC