Therapeutic Potential of Rare Sesterterpenoids from Aspergillus Variecolor Strain SDG and Docking Studies.

• Tác giả: Umme Ummarah Fariha, Ponnapalli Mangala Gowri, Koochana Pranay Kumar, Sunil Misra, Batchu Uma Rajeswari, Annam S Ch V Appa Rao, Kavya Sunkara
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Chemistry & biodiversity , 2025
• Bộ sưu tập: NCBI
• ID: 699981

Tóm tắt

Ethyl acetate extract of the cultures of the soil-derived filamentous fungus, Aspergillus variecolor SDG strain from Nallamala forest resulted in the isolation of extremely rare sesterterpenoids, stellatic acid (1) and andilesin C (2). We report a thorough chemical characterization of these compounds using various spectroscopic techniques and evaluation of their in vitro preclinical therapeutic potential. Stellatic acid exhibits potent antioxidant activity with an IC