PURPOSE: To investigate whether genetic and clinical characteristics differ depending on generations using 326 patients (male/female, 259/67
mean age, 55.4 ± 12.5 years) with simple CSC. METHODS: All patients were diagnosed with simple CSC, defined as a retinal pigment epithelium alteration area equal to or smaller than 2-disc areas based on multimodal imaging at the initial presentation. We cross-sectionally evaluated clinical characteristics at the initial visit and genotyped RESULTS: As generations decreased, the proportion of males, subfoveal choroidal thickness, and prevalence of fibrin significantly increased ( CONCLUSION: Clinical and genetic characteristics differed significantly among patients with simple CSC, depending on their generation.