Exploring the Antisnake Venom Potential of Zingiber officinale and its Bioactive Compounds Against Naja nigricollis Venom Through Computational Approaches and Experimental Validation.

• Tác giả: Musa I Abdullahi, Abayomi E Adeboyega, Nasir Ibrahim, Mustapha Salihu, Amina J Yusuf
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Chemistry & biodiversity , 2025
• Bộ sưu tập: NCBI
• ID: 700030

Tóm tắt

 Snakebite envenomation remains a significant medical challenge, particularly in tropical and subtropical regions. The present study investigates the inhibitory potential of Zingiber officinale (ginger) and its bioactive compounds against Naja nigricollis venom using in silico approaches and animal models. No protection was observed in the in vivo studies but the extract of the plant was able to prolong the time of death with mean survival time ranging from 2.01-2.83 hours. In terms of the in vitro studies, the extract was able to significantly (p<
 0.05) detoxify the N. nigricollis venom by 80 % at the graded doses
  standard antisnake venom (ASV) offered 100 % protection to mice. Molecular docking analysis revealed strong binding affinities between the bioactive compounds and the PLA