BACKGROUND: One of the conditions that might harm your eyesight is diabetic retinopathy (DR), DR may set in slowly but surely for those with long-term diabetes and poor glucose control. . OBJECTIVE: To establish a connection between the various genotypes of the rs1800624 SNP and the rs80096349 SNP located in the METHODS: The current case-control research examined one hundred thirty-four individuals diagnosed with type 2 diabetes and thirty-six healthy individuals who did not have DM. These samples were obtained from Amir Al-Muminin, a private hospital in Najaf, Iraq. The tetra primers ARMS-PCR method was utilized to determine the genotype of rs1800624 SNP of the RESULTS: A significant association was found between genotypes (AA, AG, and GG) and DR subgroups (NPDR & PDR) in patients ( CONCLUSION: The rs1800624 SNP of the