Synthesis, In-Silico Biochemical Properties, and In-Vitro Antimicrobial Activity of Some Farmazans-Sulfonamide Derivatives.

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Tác giả: Mamdouh Allahyani, Mazen Almehmadi, Meshari A Alsuwat, Mohammad Asif

Ngôn ngữ: eng

Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons

Thông tin xuất bản: Switzerland : Chemistry & biodiversity , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 700138

The low effectiveness of currently available antibiotics is driving efforts worldwide to generate new antimicrobial drugs. So, we synthesized some new formazan derivatives containing sulfonamide moiety, and assessed their in-silico biochemical properties as well as in-vitro antibacterial activity against some pathogenic Gram-positive (B. subtilis and S. aureus) and Gram-negative (E. coli and S. thyphi) bacteria and fungi (C. albicans and A. niger). These formazan derivatives were synthesized by condensing sulphanilamide with benzaldehyde in the presence of glacial acetic acid and ethanol produced a Schiff base of sulfonamide (1). After this compound 1 was reacted with substituted benzene diazonium chlorides (2a-g) by condensation reaction yields formazan derivatives (3a-g). The structures of synthesized compounds were characterized on the basis analytical and spectral (IR,
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