PURPOSE: To translate and cross-culturally adapt Fukushima Lumbar Spinal Stenosis Scale into a Simplified Chinese version (FLS-25-SC), and evaluate the reliability and validity of FLS-25-SC in patients with lumbar spinal stenosis. METHODS: Test-retest reliability was assessed by Intra-class correlation coefficient (ICC). Construct validity was analyzed by correlations between FLS-25-SC and the Swiss Spinal Stenosis (SSS) Questionnaire, Visual analogue scale (VAS) as well as the short form (36) health survey (SF-36). RESULTS: The original version of the FLS-25 was cross-culturally adapted and translated into Simplified Chinese. FLS-25-SC was indicated to have excellent reliability (Cronbach's alpha = 0.941, ICC = 0.952). FLS-25-SC had almost perfect correlation with Physical Functioning (r = -0.870, P <
0.001) subscale of SF-36. Moderate to substantial correlations between FLS-25-SC and Symptom severity (r = 0.542, P <
0.001), Physical function (r = 0.604, P <
0.001) subscales of Swiss Spinal Stenosis (SSS) Questionnaire, VAS (r = 0.613, P <
0.001), as well as Role Physical (r = -0.537, P <
0.001) and Bodily Pain (r = -0.474, P <
0.001). It was observed that the loading of the 3 factors explained 63.108% of the total variance: [Kaiser-Mayer-Olkin (KMO) = 0.903, C2 = 1769.491, p <
0.001]. CONCLUSION: FLS-25-SC has been shown to have acceptable reliability and validity in patients with degenerative lumbar spinal stenosis and may be recommended for patients in Chinese mainland.