CARMIL1-AA selectively inhibits macropinocytosis while sparing autophagy.

• Tác giả: Cecily Anaraki, Brandon Chu, Brennan M Chuang, Aimee L Edinger, Christopher J Halbrook, Rebecca M Lim, Alexa Lu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Molecular biology of the cell , 2025
• Bộ sưu tập: NCBI
• ID: 700243

Tóm tắt

Macropinocytosis is reported to fuel tumor growth and drug resistance by allowing cancer cells to scavenge extracellular macromolecules. However, accurately defining the role of macropinocytosis in cancer depends on our ability to selectively block this process. 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) is widely used to inhibit macropinocytosis but affects multiple Na