KAHA ligation as a platform for the rapid discovery of Protein Tyrosine phosphatase 1B (PTP1B) inhibitors.

• Tác giả: Liqian Gao, Lakshminarayanan Rajamani, Rajavel Srinivasan, Sijia Tan, Jing Tian
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.749 Spacecraft
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 700307

Tóm tắt

We have successfully designed and assembled a 66-member library of protein tyrosine phosphatases (PTP) inhibitor candidates using α-ketoacid-hydroxylamine (KAHA) ligation. Subsequent in situ enzymatic screening revealed a potent hit (IC