Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells.

• Tác giả: Deep Rohan Chatterjee, Moumita Ghosh Chowdhury, Saumya Kapoor, Venkatesh Muthukumar, Amit Shard
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 700408

Tóm tắt

Glioblastoma (GB), the most aggressive and life-threatening primary brain tumor in adults, poses significant therapeutic challenges. Tumor pyruvate kinase M2 (PKM2) has been implicated in the proliferation and survival of glioma cells. In this study, we designed and synthesized a series of 23 novel tetrazole-based derivatives. The compounds were thoroughly characterized using