Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation.

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Tác giả: Moustafa S Abusaif, Ghada E Ahmed, Yousry A Ammar, Eman A Fayed, Nirvana A Gohar, Ayah M H Gowifel, Soha Osama Hassanin, Ahmed Ragab

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Bioorganic chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 700444

Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary treatment option for advanced hepatocellular carcinoma. A series of fluoro-11H-indeno[1,2-b]quinoxaline derivatives as an HCC drug targeting the VEGFR2/AKT axis was designed and synthesized. The novel compounds were investigated against HepG-2 and HuH-7 liver tumor cell lines. Compound 5 was the most active derivative against HepG-2 and HuH-7 cell lines with IC
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