Synthesis of novel spiroisoxazolidino hybrids of alantolactone and isoalantolactone via 1,3 dipolar nitrone cycloaddition and its antimicrobial Evaluation.

• Tác giả: Yogesh P Bharitkar, Harshad B Bhore, Anil Kumar Katare, Diksha Kumari, Tashi Palmo, Jayanta Samanta, Kuljit Singh, Aliya Tabassum, Initha Venkatesan
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 700632

Tóm tắt

Alantolactone and isoalantolactone are two isomeric sesquiterpene lactones that were isolated from Innula recemosa. Here, we are used for the semisynthesis of novel isoxazolidine hybrids of alantolactone and isoalantolactone through a two-step process: nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The formation of the cycloadduct was well characterized via modern spectroscopic techniques such as HRMS,