Coronin1A Regulates the Trafficking of Alpha Synuclein in Microglia.

• Tác giả: Faith L Anderson, Karl E Biggs, Emma N Fikse, Matthew C Havrda, Arminja N Kettenbach
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: United States : The Journal of neuroscience : the official journal of the Society for Neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 701087

Tóm tắt

Microglia respond to cytotoxic protein aggregates associated with the progression of neurodegenerative disease. Pathological protein aggregates activate the microglial NLRP3 inflammasome resulting in proinflammatory signaling, secretion, and potentially pyroptotic cell death. We characterized mixed sex primary mouse microglia exposed to microbial stressors and alpha synuclein preformed fibrils (αsyn PFFs) to identify cellular mechanisms related to Parkinson's disease. Microglia package and release the endosome fate regulator Coronin1A (Coro1A) in EVs in an