PURPOSE: To determine the technical feasibility of discriminating discontiguous from contiguous ablation zones between a pair of microwave ablation (MWA) applicators using broadband microwave transmission signal measurements in an in vivo porcine liver model. MATERIALS AND METHODS: Dual applicator 2.45 GHz MWA was performed using 1 directional and 1 omnidirectional applicator, spaced 3 cm apart, under imaging guidance. The study involved 15 hepatic MWAs across 4 swine, with ablation durations of 200 seconds (n = 8) for discontiguous ablation and 600 seconds (n = 7) for contiguous ablation, each at 60 W
these ablation durations and applied power combinations were selected with the intent of creating discontiguous (200 s) and contiguous (600 s) ablation zones. A custom software periodically measured transmission signals between the applicators at 46-second intervals. Contrast-enhanced computed tomography (CT), gross pathology, and histopathologic analyses were used to assess the processed transmission signal (PTS). RESULTS: Statistical analyses revealed significant differences between contiguous and discontiguous ablation zones on contrast-enhanced CT imaging (volume, 16.9 cm CONCLUSIONS: This study demonstrated that PTS between dual MWA applicators can distinguish between contiguous and discontiguous ablation zones.