Extracellular Mitochondrial-Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction.

• Tác giả: Lianglong Chen, Zhenning Dai, Wenhua Huang, Ziwei Jiang, Shiyu Li, Ziyue Li, Yilin Wang, Zi Yan, Jiaxin Yang, Lei Yang, Qiuyi Yu, Xinyi Yun, Huihui Zhang, Weihan Zheng, Hai Zhou, Junyou Zhu
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 701355

Tóm tắt

Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20)