Synergistic Cancer Photoimmunotherapy by Harnessing Near-Infrared-Activated Nanoparticles Containing Charge Transfer Complexes.

• Tác giả: Zaid Alkalani, Yuanning Feng, Aaron J Lim, Kade P Littlefield
• Ngôn ngữ: eng
• Ký hiệu phân loại: 149.73 Skepticism
• Thông tin xuất bản: Germany : Angewandte Chemie (International ed. in English) , 2025
• Bộ sưu tập: NCBI
• ID: 701524

Tóm tắt

Phototherapy-which includes photothermal therapy (PTT) and photodynamic therapy (PDT)-has evoked interest as a promising cancer treatment modality on account of its noninvasiveness, spatiotemporal precision, and minimal side effects. C. Wang et al. recently reported a near-infrared-activated charge transfer complex-based nanoparticle which consists of a donor (D) and an acceptor (A). Experimental results have demonstrated a potent immunotherapeutic effect of integrating programmed cell death protein 1 antibody combination therapy in preclinical models. Incorporating D-A interactions into nanosystems for photoimmunotherapy (PIT) is still a novel approach. This approach offers a multifaceted strategy for synergistic cancer PIT which holds promising potential to transform cancer treatment paradigms.