Functional assays for the diagnosis of chronic granulomatous disease.

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Tác giả: Danielle L Fink, Douglas B Kuhns, Karen Lau, Debra Long Priel

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : Journal of immunological methods , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 701776

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Chronic granulomatous disease (CGD) is a rare immunodeficiency characterized by recurrent bacterial and fungal infections that are attributed to reduced production of reactive oxygen species (ROS) by a multi-component enzyme complex known as the phagocyte NADPH oxidase or NOX2. Presented in this review are descriptions of several assays that assess the production of ROS as well as assays that characterize the expression of specific proteins of NOX2.

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