BACKGROUND: Traditionally, intramuscular vitamin B OBJECTIVE: We investigated changes between 2015 and 2024 in prescribing B DESIGN, POPULATION AND SETTING: This was an observational study of general practice in England covering 100% of the population. METHODS: We used prescribing data published by the NHS Business Service Authority. Monthly prescription counts and rates per 100 000 patients were visualised in longitudinal plots from 1 January 2015 to 30 September 2024. We stratified the analysis by regions in England. Changes in yearly counts and rates were summarised using descriptive statistics. Linear regression and data from before the COVID-19 pandemic were used to model trends from 2020 to 2024 as if the pandemic had not occurred. The predicted values and their 95% CI were used to assess the effect of the pandemic. RESULTS: The number of prescriptions for B CONCLUSIONS: In this study, we document important changes to vitamin B