Crystallization of supersaturated PEG-b-PLA for the production of drug-loaded polymeric micelles.

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Tác giả: Rae Hyung Kang, Maraya Klukas, Glen S Kwon, Morteza Rasoulianboroujeni

Ngôn ngữ: eng

Ký hiệu phân loại: 359.9 Specialized combat forces; engineering and related services

Thông tin xuất bản: Netherlands : Journal of controlled release : official journal of the Controlled Release Society , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 701930

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In this study, we propose the "crystallization from supersaturated solution" method for producing drug-loaded polymeric micelles. This method involves the formation of solid drug-encapsulating crystals of a diblock copolymer through isothermal crystallization from a supersaturated solution of the copolymer in low molecular weight PEGs containing the drug, followed by dissolution of the crystals to obtain drug-loaded micelles. We fabricated and characterized micelles loaded with several model drugs (paclitaxel, rapamycin, and docetaxel) and their oligo(lactic acid)

1. Crystallization
2. Of
3. Supersaturated

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