Total bile acid is a useful tool for evaluating the risk of portal hypertension in patients with hepatocellular carcinoma who have undergone hepatectomy.

• Tác giả: Xi He, Li-Xin Li, Zhi-Jie Li, Zhen-Wen Liu, Xiao-Feng Niu, Hui Ren, Da-Li Zhang, Xiao-Feng Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 373.236 Lower level
• Thông tin xuất bản: England : Current medical research and opinion , 2025
• Bộ sưu tập: NCBI
• ID: 701945

Tóm tắt

 OBJECTIVE: Evaluating portal hypertension is crucial for patients with hepatocellular carcinoma (HCC) who are candidates for liver resection. Total bile acid (TBA) is an easily accessible marker, but its potential as a non-invasive indicator of portal hypertension in patients with HCC is yet to be fully established. METHODS: This study included patients with HCC classified as Child-Pugh stage A who underwent liver resection at a referral hospital. Elevated TBA levels were defined as serum TBA >
 10 μmol/L, while normal levels were ≤10 μmol/L. RESULTS: A total of 167 patients with HCC with Child-Pugh Class A who underwent liver resection were analyzed. The cohort was divided into normal ( CONCLUSION: Elevated TBA levels in patients with HCC with Child-Pugh class A are significantly associated with portal hypertension and a higher incidence of post-hepatectomy liver failure.