An estimated 190 million women are affected by endometriosis worldwide yet delays in diagnosis and treatment and validation of patient symptoms remain significant barriers to care. While a lack of data and gaps in research are central to understanding and addressing this disease, researchers are developing some promising innovations. In this column, I review prevalence and symptoms, barriers to diagnosis, and new innovations in care for endometriosis and the implications for research, practice, and policy. I conclude with information from professional organizations and the need for updated clinical guidelines.