Early Life Stress Impairs VTA Coordination of BLA Network and Behavioral States.

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Tác giả: Pantelis Antonoudiou, Jamie L Maguire, Garrett Scarpa, Bradly T Stone, Eric Teboul, Grant Weiss

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : The Journal of neuroscience : the official journal of the Society for Neuroscience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 702064

Motivated behaviors, such as social interactions, are governed by the interplay between mesocorticolimbic structures, such as the ventral tegmental area (VTA), basolateral amygdala (BLA), and medial prefrontal cortex (mPFC). Adverse childhood experiences and early life stress (ELS) can impact these networks and behaviors, which is associated with increased risk for psychiatric illnesses. While it is known that the VTA projects to both the BLA and mPFC, the influence of these inputs on local network activity which govern behavioral states-and whether ELS impacts VTA-mediated network communication-remains unknown. Our study demonstrates that VTA inputs influence BLA oscillations and entrainment of mPFC activity in mice and that ELS weakens the ability of the VTA to coordinate BLA network states, while also impairing dopaminergic signaling between VTA and BLA. Optogenetic stimulation of VTA
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