TNF/IFN-γ Co-Signaling Induces Differential Cellular Activation in COVID-19 Patients: Implications for Patient Outcomes.

• Tác giả: Ivette Buendia-Roldan, Leslie Chavez-Galan, Ramcés Falfán-Valencia, Julio Flores-Gonzalez, Alberto López-Reyes, Carlos Martinez-Armenta, Laura Edith Martínez-Gómez, Gabriela Angélica Martínez-Nava, Karen Medina-Quero, Ranferi Ocaña-Guzmán, Gloria Pérez-Rubio, Lucero A Ramón-Luing, Moisés Selman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.37 Testing and measurement of electrical quantities
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 70210

Tóm tắt

TNF and IFN-γ are key proinflammatory cytokines implicated in the pathophysiology of COVID-19. Toll-like receptor (TLR)7 and TLR8 are known to recognize SARS-CoV-2 and induce TNF and IFN-γ production. However, it is unclear whether TNF and IFN-γ levels are altered through TLR-dependent pathways and whether these pathways mediate disease severity during COVID-19. This study aimed to investigate the association between TNF/IFN-γ levels and immune cell activation to understand their role in disease severity better. We enrolled 150 COVID-19 patients, who were classified by their systemic TNF and IFN-γ levels (high (H) or normal-low (N-L)) as TNF