Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.

• Tác giả: Akindele O Adebiyi, Ben Adusei, Ilir Agalliu, Oseremen I Aisuodionoe-Shadrach, Caroline Andrews, Sonja I Berndt, William Blot, Clinton L Cario, Stephen J Chanock, Wenlong C Chen, David V Conti, Burcu F Darst, Scott Eggener, Karen Feng, Pedro W Fernandez, Neal D Freedman, Phyllis J Goodman, Louisa B Goss, Rebecca E Graff, Christopher A Haiman, Thomas J Hoffmann, Wen-Yi Huang, Mohamed Jalloh, Rohini Janivara, Yu Jiang, Amy C Justice, Linda Kachuri, Robert J Klein, Joseph Lachance, Shengchao A Li, Hans Lilja, Jirong Long, Mitchell J Machiela, Ravi K Madduri, James E Mensah, Jonathan D Mosley, Brandon L Pierce, Joseph Presti, Dilrini K Ranatunga, Timothy Rebbeck, Alex A Rodriguez, Kerry Schaffer, John P Shelley, Ian Thompson, Cathee Till, Lin Tong, Stephen K Van Den Eeden, Anqi Wang, John S Witte
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Nature genetics , 2025
• Bộ sưu tập: NCBI
• ID: 702124

Tóm tắt

 We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry
  96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (P ≤ 5 × 10