BACKGROUND: Criminal legal involvement (CLI) has been associated with increased burden of disease, worse health outcomes, and high healthcare utilization. The health needs of women with CLI are often overlooked despite the rising proportion of women in the US legal system. OBJECTIVE: Examine differences by binary gender in the prevalence of disease and healthcare utilization among individuals with lifetime CLI. DESIGN/SETTING: Cross-sectional nationally representative multivariate logistic regression and negative binomial regression. PARTICIPANTS: Adult respondents with lifetime CLI (N = 37,279) with response rate of 66-69%. MEASURES: The primary independent variable was binary gender (woman/man). Outcomes included medical conditions, substance use disorders, mental illness, and healthcare utilization. Covariates included sociodemographic confounders. RESULTS: Women comprised 29.1% of respondents with lifetime CLI and reported 0.83 times the odds of chronic heart disease compared to men (95%CI 0.74, 0.92
p = 0.001), but 1.86 times the odds of COPD (95%CI 1.63, 2.13
p <
0.001), 1.78 times the odds of asthma (95%CI 1.63, 1.93
p <
0.001), and 1.30 times the odds of cancer (95%CI 1.08, 1.53
p = 0.005). While women were less likely to have a substance use disorder (OR 0.84
95%CI 0.78, 0.90), they were more likely to currently smoke (OR 1.29, 95%CI 1.20, 1.28
p <
0.001) and to have any mental illness (OR 2.45
95%CI 2.26, 2.63
p <
0.001). Women reported increased rates of all forms of healthcare utilization compared to men after adjustments. CONCLUSIONS: Women with lifetime CLI experience a different profile of diseases compared to men with increased prevalence of any mental illness and chronic disease, especially respiratory diseases. They also had higher rates of healthcare utilization. Additional research should focus on interventions tailored to the unique needs of this population.