The extremely low sliding friction of articular cartilage in synovial joints has been attributed to phospholipid boundary layers, lubricating via the hydration lubrication mechanism at their exposed, highly hydrated polar-head-groups, in a medium - the synovial fluid - where osmolytes, which may modify the hydration layer, are ubiquitous. Here, using a surface force balance (SFB), we carried out a systematic study to elucidate the effect of sucrose, a known osmotic regulator solute, with concentrations c