CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts.

• Tác giả: Sandy Chen, Ryoji Fujii, Rie Komatsu, Hisateru Niki, Toru Ogasawara, Yodo Sugishita, Yuki Suzuki-Takahashi, Kazuo Yudoh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.123 Mishnah
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 70225

Tóm tắt

Palbociclib, a dual CDK4/6 kinase inhibitor used for breast cancer, has been explored as a treatment option for rheumatoid arthritis (RA). Preclinical studies have reported palbociclib-induced myelosuppression, but no such effects have been observed in