Deep-learning based Embedding of Functional Connectivity Profiles for Precision Functional Mapping.

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Tác giả: Babatunde Adeyemo, Adam T Eggebrecht, Jed T Elison, Jung-Hoon Kim, Patrick Luckett, Joshua S Shimony, Jiaxin Cindy Tu, Muriah D Wheelock

Ngôn ngữ: eng

Ký hiệu phân loại: 564 Fossil Mollusca and Molluscoidea

Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 702312

Spatial correlation of functional connectivity profiles across matching anatomical locations in individuals is often calculated to delineate individual differences in functional networks. Likewise, spatial correlation is assessed across average functional connectivity profiles of groups to evaluate the maturity of functional networks during development. Despite its widespread use, spatial correlation is limited to comparing two samples at a time. In this study, we employed a variational autoencoder to embed functional connectivity profiles from various anatomical locations, individuals, and group averages for simultaneous comparison. We demonstrate that our variational autoencoder, with pre-trained weights, can project new functional connectivity profiles from the vertex space to a latent space with as few as two dimensions, yet still retain meaningful global and local structures in the data. Functional connectivity profiles from various functional networks occupy distinct compartments of the latent space. Moreover, the variability of functional connectivity profiles from the same anatomical location is readily captured in the latent space. We believe that this approach could be useful for visualization and exploratory analyses in precision functional mapping.
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