Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice.

• Tác giả: Daina M Cleveland, Cheryl A Frye, Anjali Sadarangani, Jennifer K Torgersen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 347.053 Kinds of actions
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 70250

Tóm tắt

 Progestogens' anti-anxiety and anti-depressive effects and mechanisms are not well-understood. Progestogens are hypothesized to have anti-anxiety and anti-depressive effects on behavior, independent of actions at nuclear progestin receptors (NPRs) and dependent on allopregnanolone (5α-pregnan-3α-ol-20-one
  3α,5α-THP), a 5α-reduced, neuroactive metabolite of progesterone (P