The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation.

• Tác giả: Daniel P Cook, R Stokes Peebles
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Immunological reviews , 2025
• Bộ sưu tập: NCBI
• ID: 702506

Tóm tắt

Cystic fibrosis (CF) is a common autosomal recessive disease resulting from mutations of the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR). Although severe pulmonary neutrophilic inflammation is a primary pathologic feature of CF, more recent studies reveal a role for type 2 inflammation that is characterized by eosinophilia directed by both the innate and adaptive immune systems through ILC2 and CD4